The injections were not placed in the typical locations of the headache pain, but in areas normally injected during plastic surgery. In subsequent studies, using larger doses and injecting into more specific localities for the headache pain, the results were improved. These tests were concerning migraine headaches. However, with tension headaches, or muscle tension headaches, the studies have shown improved results. This is to be expected due to the weakening or paralyzing nature of Botox on the muscles that are experiencing tension. When being injected with Botox for the prevention of headaches it may take several weeks before the injection takes effect. For this reason it is usually necessary to have it injected no more often than once every 3 months or so. People that have Botox administered for the treatment of headaches typically need it injected every few months. If there is too long of an interval between injections the headaches may be experienced by the patient.However, the question arises about the safety of these regular injections of a neurotoxin. Since 1989, when it was first used as a headache treatment, it has appeared to be fairly safe. Most migraine headache medications are taken orally and eventually end up in the blood stream. Because of this common symptoms of migraine headache medication will be dizziness and drowsiness among other symptoms. Since Botox is injected directly into the muscle tissue and does not get absorbed into the blood system as does the typical headache medicine there are fewer side effects. Most commonly, the only side effects of injecting this neurotoxin is pain in the area of injection for a couple of days or drooping of the eyelids for a few days.Studies are still being performed on this medication and as yet the FDA has not approved it for the treatment of headaches. However, physicians do prescribe it to their patients and if you think you are a candidate to use it you should discuss it with your doctor. If you do not respond to other headache medications it may be something to talk with your physician about. As the studies continue the effects and safety issues involving this medication should become more clear.