Chemotherapy, and some other causes may lead to bone marrow suppression -- a decrease in the ability of the bone marrow to produce blood cells. Reduced blood cells make people to be susceptible to infections, and in some cases death occurs. Now, scientists find that deleting or switching off a gene Grb10 blood stem cells (Hematopoietic stem cells (HSCs) ) can enhance their regeneration ability. The findings may lead to new therapeutic drugs for patients with damaged bone marrow. The study, directed by John P. Chute in Department of Medicine of UCLA, appears in Cell Reports. They removed bone marrow from mice and then transplanted blood stem cells that did not express Grb10. Results showed that these stem cells multiply more rapidly. The team studied mouse blood stem cells exposed to irradiation and from normal mice. The blood stem cells that had been exposed to irradiation had higher Grb10 levels than normal blood stem cells. When the researchers deleted the gene in the blood stem cells, it increases their ability to renew and renew. Grb10 loss improved the regeneration ability of blood stem cells. CusAb has Grb10 protein and polyclonal antibody. Next, they transplanted normal HSCs and Grb10-deficient HSCs to mice exposed to irradiation. Results showed that Grb10-deficient HSCs exhibited more powerful regeneration ability, suggesting that inhibition of Grb10 might be a way to improve blood cell production.