In the production Insulin Syringe Assembly Machine of the rotary tablet press, there are often cases where the compressed tablets cannot be disintegrated within the prescribed time limit, which affects the dissolution, absorption and efficacy of the drug. When the hardness of the granule is small, it is easy to be broken due to compression, and the tablet disintegrates slowly; on the contrary, when the hardness of the granule is large, the tablet disintegrates faster. According to the industry, in general, the greater the pressure, the slower the tablet disintegration. Second, the hardness of the particles. Fourth, lubricants and surfactants. The hydrophobic lubricants commonly used in tablets may also seriously affect the wettability of the tablets and accelerate the disintegration of the tablets. There is also a reaction in the industry. Therefore, the four main factors that affect the penetration of the disintegration medium (moisture) into the tablet are the number of capillaries, capillary pore size, liquid surface tension and contact angle. Among them, the rotary tablet press is the basic equipment suitable for mass production by compressing various granular materials into round tablets and special-shaped tablets. Correct installation and reasonable operation, as well as regular maintenance of the rotary tablet press, will help extend its service life. The influencing factors of tablet disintegration include the following parts: First, the compressibility of the raw materials. The causes of tablet fragments include excessive pressure, incompatible punches, and rotational speed. The storage conditions of the tablets are also very important. When the hydrophobic lubricant and the particles are mixed for a long time and the mixing intensity is greater, the surface of the particles will be more completely covered by the hydrophobic lubricant. Therefore, the pore wall of the tablet has strong hydrophobicity, which can significantly extend the disintegration time. Common tablet presses can be divided into high-speed rotary tablet presses and single-type presses. What is going on? What? How to solve it? According to the industry, the general disintegration medium is water or artificial gastric juice, and its viscosity does not change much. However, in the operation of the equipment, some faults often occur, which require users' attention.. It is reported that the compressible raw and auxiliary materials are prone to plastic deformation when compressed, and the disintegration of tablets is slow
