Human biofluids, like human sweat, could serve as an excellent and sustainable bioenergy resource for powering long run e-skin gadgets (twenty five, 26). Moreover, they consist of a wealth of chemical substances which can replicate an individual’s health and fitness standing (27-29). Current improvements in wearable sweat analysis have enabled quite a few fundamental and scientific programs, like noninvasive metabolic monitoring and disease analysis (30-32). Below, we report a battery-free, thoroughly perspiration-powered electronic skin (ppES) that harvests power from human sweat by way of lactate biofuel cells (BFCs), performs ongoing multiplexed monitoring of key metabolic biomarkers ( glucose, urea, NH4+, and pH), and wirelessly transmits the individualized data to some user interface by way of Bluetooth lower electrical power (BLE) (Fig. 1A). Created on an ultrasoft polymeric substrate, the ppES can comply with the skin’s modulus of elasticity and conformally laminate on unique human body sections for precise biosensing (Fig. one, B and C). Working with cross-dimensional nanomaterial integration, the remarkably productive and steady nanoengineered BFC array was able to reach a record-breaking and sustainable high-power density, enabling steady self-powered health checking.