Mycoplasma is the smallest prokaryotic organism that can live independently. Urethritis symptoms may occur once mycoplasma infection occurs in patients , and secondarily to chronic prostatitis, testis and epididymitis, but also can cause obstruction of the vas deferens leading to azoospermia. Mycoplasma also continues to infect seminal tract, seminal vesicle and testis, affecting the quality of sperm and semen and causing male infertility. How does mycoplasma cause male infertility? Destruction of spermatogenic cells: There are a large number of spermatogenic cells in the seminiferous tubules of testis. These spermatogenic cells develop and reproduce to form sperm. When mycoplasmaenters testicular seminiferous tubules from urethra and prostate, it will destroy spermatogenic cells and make "spermatogenic factory" produce fake and inferior products,leading to infertility. Increased rate of sperm malformation: Another feature of infertility is increased rate of sperm malformation caused by mycoplasmainfection. According to clinical observation, sperm malformation rate can sometimes be as high as 80% in such infertile patients. Disturbance of sperm motility: Sperm motility is an important function of healthy sperm and an important indicationwhether sperm can conceive, and sperm motility must have a certain speed and frequency. Mycoplasmaoften attaches to the head and tail of sperm after infecting, which makes the whole sperm full of attachments of different sizes, resulting in inability of sperm to swim and entanglement with each other, and then leading to infertility. The number of sperm with fertility decreased, motility decreased, morphological abnormalities, and some of them lost the ability to enter and bind to the egg. Neuraminidaseproduced by mycoplasma can interfere the combination of sperm and ovum. This is one of the causes of infertility caused by mycoplasma infection. Mycoplasma urealyticum infection also has common antigens with sperm membrane. Once infected, it may lead to immune infertility. Patient with positive mycoplasma must be treated in time. Mycoplasma infection can be treated with Diuretic and Anti-inflammatory Pill, which has the efficacy of sterilization, anti-inflammatory, promoting blood circulation and removing blood stasis, diuresis and drenching. And daily hygiene is essential.